Letter in response to glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning.
نویسندگان
چکیده
TSP1–CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction N. M. Rogers, M. Sharifi-Sanjani, M. Yao, K. Ghimire, R. Bienes-Martinez, S. M. Mutchler, H. E. Knupp, J. Baust, E. M. Novelli, M. Ross, C. St. Croix, J. C. Kutten, C. A. Czajka, J. C. Sembrat, M. Rojas, D. Labrousse-Arias, T. N. Bachman, R. R. Vanderpool, B. S. Zuckerbraun, H. C. Champion, A. L. Mora, A. C. Straub, R. A. Bilonick, M. J. Calzada, and J. S. Isenberg 15
منابع مشابه
Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning
AIMS Although the nature of the humoral factor which mediates cardioprotection established by remote ischaemic conditioning (RIc) remains unknown, parasympathetic (vagal) mechanisms appear to play a critical role. As the production and release of many gut hormones is modulated by the vagus nerve, here we tested the hypothesis that RIc cardioprotection is mediated by the actions of glucagon-like...
متن کاملRemote ischaemic conditioning: cardiac protection from afar
For patients with ischaemic heart disease, remote ischaemic conditioning may offer an innovative, non-invasive and virtually cost-free therapy for protecting the myocardium against the detrimental effects of acute ischaemia-reperfusion injury, preserving cardiac function and improving clinical outcomes. The intriguing phenomenon of remote ischaemic conditioning was first discovered over 20 year...
متن کاملRemote ischaemic pre- and delayed postconditioning – similar degree of cardioprotection but distinct mechanisms
Myocardial ischaemia-reperfusion injury can be significantly reduced by an episode(s) of ischaemia-reperfusion applied prior to or during myocardial ischaemia (MI) to peripheral tissue located at a distance from the heart; this phenomenon is called remote ischaemic conditioning (RIc). Here, we compared the efficacy of RIc in protecting the heart when the RIc stimulus is applied prior to, during...
متن کاملGlucagon-Like Peptide-1
Ma Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have demonstrated cardioprotection from ischemia-reperfusion injury. It can reduce infarct size, ischemic left ventricular dysfunction, and myocardial stunning. GLP-1 receptor agonists have also been shown to reduce ...
متن کاملCardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart
Previous studies have shown that glucagon-like peptide-1 (GLP-1) provides cardiovascular benefits independent of its role on peripheral glycemic control. However, the precise mechanism(s) by which GLP-1 treatment renders cardioprotection during myocardial ischemia remain unresolved. Here we examined the role for GLP-1 treatment on glucose and fatty acid metabolism in normal and ischemic rat hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cardiovascular research
دوره 113 1 شماره
صفحات -
تاریخ انتشار 2017